NHP IL-10 Analyte Overview
NHP IL-10
Also known as Interleukin 10, human cytokine synthesis inhibitory factor (CSIF), CSIF, IL10A, MGC126450, MGC126451, TGIF
Interleukin 10 (IL-10) is a class-2 anti-inflammatory cytokine, also known as human cytokine synthesis inhibitory factor (CSIF). It impacts many areas of immunoregulation and inflammation, with numerous pleiotropic effects in the immune system. As an anti-inflammatory, it downregulates MHC class II expression, inhibits the synthesis and activity of many inflammatory cytokines, and reduces co-stimulatory factors on macrophages. It also enhances the release of other anti-inflammatory mediators by monocytes and macrophage, particularly during exercise. It enhances B cell proliferation, differentiation, survival, and antibody production. IL-10 has anti-tumor effects, reducing tumor growth and decreasing metastatic burden in the body. IL-10 deficiency is associated with chronic inflammatory and autoimmune diseases, including multiple sclerosis, Crohn’s disease, inflammatory bowel disease, psoriasis, and rheumatoid arthritis. IL-10 is currently under investigation as a potential therapeutic for many conditions, including cancer treatments and reducing symptoms in inflammatory disorders.
Typical Assay Characteristics
| Precision | Linearity | ||
|---|---|---|---|
| Inter-assay | Intra-assay | Range | Average |
| 13% | 4% | 92%-120% | 102% |
Q-Plex™ Details
Species: NHP
Assay Type: Sandwich
Sample Type: Serum/Plasma, Cell Supernatant
Assay Range: 2,680 – 3.68 pg/mL
Lower Limit of Detection (LLD): 1.84 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Features & Requirements
- Data available as fast as 4 hours
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays
Featured Q-Plex Products
Q-Plex™ NHP Anti-Inflammatory Panel 1 (7-Plex)
IL-1RA, IL-2Rα, IL-4, sIL-6R, IL-10, IL-13, TNFRII
Q-Plex™ NHP Cytokine Screen (16-Plex)
CXCL-1, GMCSF, IFNγ, IL-1ß, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-15, IL-17A, IL-18, TNFα
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