NHP CXCL-1 Analyte Overview
NHP CXCL-1
Also known as Chemokine Ligand 1, GROα, KC, CINC-1, Neutrophil-activating protein 3 (NAP-3), GRO1, Melanoma Growth Stimulating Activity alpha (MGSA-α)
CXCL-1 or GROα, is a proinflammatory chemokine that plays a role in immune responses and many cancers. In the healthy immune system, CXCL-1/GROα is produced by monocytes, epithelial cells, and fibroblasts in response to inflammatory activity. It induces neutrophil migration through chemotaxis and has antimicrobial effects. It is also capable of promoting lymphatic tube and blood vessel formation within the circulatory system. In individuals with chronic inflammatory diseases, it is produced at high levels by many cell types. Abnormally high levels of CXCL-1 stimulate the growth of tumors and are particularly associated with melanomas due to their normal expression in epithelial cells.
Typical Assay Characteristics
| Precision | Linearity | ||
|---|---|---|---|
| Inter-assay | Intra-assay | Range | Average |
| 8% | 4% | 73%-119% | 94% |
Q-Plex™ Details
Species: NHP
Assay Type: Sandwich
Sample Type: Serum/Plasma, Cell Supernatant
Assay Range: 2,000 – 2.74 pg/mL
Lower Limit of Detection (LLD): 1.37 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Features & Requirements
- Data available as fast as 4 hours
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays
Featured Q-Plex Products
Q-Plex™ NHP Chemokine Screen (9-Plex)
CXCL-1, IL-8, IP-10, MCP-1, MIF, MIG, MIP-1α, MIP-1ß, RANTES
Q-Plex™ NHP Cytokine Screen (16-Plex)
CXCL-1, GMCSF, IFNγ, IL-1ß, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-15, IL-17A, IL-18, TNFα
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