Human MMP2 Analyte Overview
Human MMP2
Also known as MMP-2, MMPII, TBE-1, Matrix Metalloproteinase-2, 72 kDa type IV Collagenase, Gelatinase A, CLG4, CLG4A, MONA
Matrix metalloproteinase 2 (MMP2), also known as gelatinase A, is an enzyme capable of breaking down type IV collagen. It is a member of the MMP family, a group of structural related zinc-dependent endopeptidases that are involved in breaking down different components of tissue. MMP2 degrades basement membranes made of type IV collagen, particularly during the menstrual cycle and early embryonic development. Overactivity of MMP2 is associated with severe chronic airway diseases, particularly pneumonia and bronchiectasis. Elevated MMP2 is associated with many types of cancer, where it’s effects on tumor progression are well documented – it supports tumor invasion into tissue, alters cell signaling to dampen immune response to the tumor, and promotes tumor blood vessel formation. Given MMP2’s role in multiple aspects of cancer biology, it is under investigation as a potential target for cancer medications.
Q-Plex™ Details
Species: Human
Sample Type: Human Serum, EDTA Plasma
Assay Range: 80,000 – 329.22 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Features & Requirements
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis
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