Human IP-10 Analyte Overview

Interferon gamma-induced protein 10 (IP-10), also known as C-X-C motif chemokine 10 (CXCL10) or small-inducible cytokine B10, is a small cytokine with diverse roles in the immune system. Many cell types release IP-10 in response to stimulation from IFN-γ. It has chemotactic properties for activated T cells, monocytes, macrophages, natural killer cells, and dendritic cells. It promotes the adhesion of T cells to endothelial cells and has strong anti-tumor properties. It inhibits bone marrow colony formation and angiogenesis. IP-10 expression has been associated with HIV-1 infection, where it contributes to the accumulation of activated T cells in the cerebrospinal fluid compartment of infected individuals. The retroviral transactivator, HIV-1 Tat, is a potent inducer of IP-10 expression in astrocytes. IP-10 expression has also been shown to be significantly elevated in astrocytes within the brains of Alzheimer’s disease patients, where its expression is associated with senile plaques. Higher levels of IP-10 are documented in Hepatitis C patients who respond poorly to antiviral treatment.

Intra-assay (n=20)
Average Intra-assay CV: 5%

Sample	Concentration (pg/ml)	%CV
Sample 1	770.42	6%
Sample 2	50.73	5%
Sample 3	16.40	4%

 

Average percent linearity: 100%
Percent linearity range: 88 – 119%

Dilution Factor	% Recovery
	Activated Plasma	Pooled Plasma	Serum HE	Cell Culture Supernatant
2	110%	104%	119%	107%
4	98%	96%	88%	98%
8	102%	98%	89%	93%