Human HGF Analyte Overview

Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a paracrine factor involved in cellular growth, motility, and morphogenesis. It plays an important role in embryonic development, wound healing, and adult organ maintenance, particularly for muscle cells. HGF causes epithelial cells, hepatocytes, keratinocytes, endothelial cells, melanocytes, and chondrocytes to proliferate and migrate during tissue formation. During early organ formation, it promotes morphogenesis by inducing cell scattering and regulating organization into structures. In adults, HGF is secreted at sites of tissue damage. High levels of serum HGF is present in conditions such as liver damage, acute kidney failure, type 1 diabetes, obesity, cancer, and myocardial infarction. High levels of HGF is are often present in the synovial fluid of patients with rheumatoid arthritis. HGF is currently being explored as a potential therapeutic for tissue repair in cardiac disease patients.

Sample	Concentration (pg/ml)	%CV
Sample 1	3297.11	5%
Sample 2	223.22	8%
Sample 3	71.37	2%

Intra-assay (n=20)
Average Intra-assay CV: 5% 

Dilution Factor	% Recovery
	Serum HB	Serum HC	PI Plasma	Stripped Serum
2	99%	92%	103%	99%
4	95%	87%	102%	107%
8	88%	85%	96%	99%

Average percent linearity: 96%
Percent linearity range: 85 – 107%