Mouse IL-10 Analyte Overview
Mouse IL-10
Also known as Interleukin 10, human cytokine synthesis inhibitory factor (CSIF), CSIF, IL10A, MGC126450, MGC126451, TGIF
Interleukin 10 (IL-10) is a class-2 anti-inflammatory cytokine, also known as human cytokine synthesis inhibitory factor (CSIF). It impacts many areas of immunoregulation and inflammation, with numerous pleiotropic effects in the immune system. As an anti-inflammatory, it downregulates MHC class II expression, inhibits the synthesis and activity of many inflammatory cytokines, and reduces co-stimulatory factors on macrophages. It also enhances the release of other anti-inflammatory mediators by monocytes and macrophage, particularly during exercise. It enhances B cell proliferation, differentiation, survival, and antibody production. IL-10 has anti-tumor effects, reducing tumor growth and decreasing metastatic burden in the body. IL-10 deficiency is associated with chronic inflammatory and autoimmune diseases, including multiple sclerosis, Crohn’s disease, inflammatory bowel disease, psoriasis, and rheumatoid arthritis. IL-10 is currently under investigation as a potential therapeutic for many conditions, including cancer treatments and reducing symptoms in inflammatory disorders.
Q-Plex™ Details
Species: Mouse
Assay Type: Sandwich
Sample Type: Serum/Plasma
Assay Range: 667 – 0.91 pg/mL
Lower Limit of Detection (LLD): 0.46 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Features & Requirements
- Measure IL-10 in 2.25 hours
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis
Featured Q-Plex Products
Q-Plex™ Mouse Cytokine Inflammation HS (13-Plex)
GMCSF, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12p70, IL-17A, MIP-1α, RANTES, TNFα
Q-Plex™ Mouse Cytokine Panel 1 HS (6-Plex)
IFNγ, IL-1α, IL-1β, IL-6, IL-10, TNF
Q-Plex™ Mouse Cytokine Screen HS Stripwells (15-Plex)
GMCSF, IFNγ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-17A, MIP-1α, RANTES, TNFα
Q-Plex™ Mouse Cytokine Screen HS (15-Plex)
GMCSF, IFNγ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-17A, MIP-1α, RANTES, TNFα
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