NHP IL-15 Analyte Overview
NHP IL-15
Also known as Interleukin 15
Interleukin 15 (IL-15) is a common cytokine that is similar to IL-2 structurally and functionally and plays an important role in the innate immune system. IL-15 stimulates the proliferation of T-lymphocytes and natural killer cells, and assists in their maintenance, activation, and differentiation. Research on Interleukin 15 and its receptor complex indicate involvement in processes such as aging, cell maturation, and regulation of cellular processes. Overexpression of IL-15 is associated with pediatric asthma, Celiac disease, and non-alcoholic fatty liver disease, and anti-IL-15 therapeutics are under investigation for the treatment of these conditions. In cancer biology, IL-15 displays anti-tumor properties and is being reviewed as a component of both anti-viral and anti-tumor vaccines. IL-15 is a target of particular interest for patients with both HIV infection and cancer, as it appears to support improved both tumor reduction and improved immune function.
Typical Assay Characteristics
Precision | Linearity | ||
---|---|---|---|
Inter-assay | Intra-assay | Range | Average |
18% | 7% | 88%-109% | 97% |
Q-Plex™ Details
Species: NHP
Assay Type: Sandwich
Sample Type: Serum/Plasma, Cell Supernatant
Assay Range: 3,578 – 4.91 pg/mL
Lower Limit of Detection (LLD): 2.45 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Features & Requirements
- Data available as fast as 4 hours
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays
Featured Q-Plex Products
Q-Plex™ NHP Cytokine Screen (16-Plex)
CXCL-1, GMCSF, IFNγ, IL-1ß, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-15, IL-17A, IL-18, TNFα
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